Bioavailability of CBD (Why It Matters)

New and experienced CBD users are asking the same question: how do we maximize the effectiveness of CBD? The answer, as it turns out, is not that simple. However, one of the most prominent factors is bioavailability. Before we get into that, let’s explore the potential benefits of CBD.

What Is CBD Anyways?

Cannabidiol can potentially be one of the most popular remedies for chronic pain. More commonly known as CBD, cannabidiol is one of the 104 cannabinoids found in cannabis. Most people know that tetrahydrocannabinol (THC) is the primary psychoactive ingredient in cannabis. THC is responsible for the “high” most people experience after smoking cannabis. CBD differs in that it is not known to contain psychoactive properties.

Since it may lack psychoactive properties, CBD can be a popular choice for those seeking pain relief without the euphoria induced by cannabis or pharmaceuticals.

CBD itself is an oil that is extracted from cannabis and subsequently diluted with some sort of carrier such as hemp oil or coconut oil. It is becoming increasingly popular in the public sphere due to its supposed healing properties and minimal side effects. Some recent studies even claim that CBD could help treat conditions like anxiety and depression.

The Potential Benefits of CBD

In regards to CBD’s potential to relieve anxiety and depression, the oil has been celebrated amongst patients with chronic anxiety and severe depression. Typically, these conditions are treated with pharmaceuticals, which may lead to a broad range of unsavory side effects that include insomnia, headaches, sexual deficiencies, drowsiness, depression, and more.

CBD may also help patients avoid addictive medications like benzodiazepines, which can lead to their own side effects as well as substance abuse. One clinical study involved two groups of people suffering from a social anxiety disorder. One group was given 600 mg of CBD while another was given a placebo. The study claims the former group reported reduced anxiety and demonstrated substantial cognitive improvement compared to the latter group.

CBD has also been used in several reputable clinical trials to assist with insomnia in individuals suffering from post-traumatic stress disorder. Additionally, CBD has been reported as being beneficial for animals, where it has allegedly exhibited effects similar to those of antidepressants. All of this is purported to be due to CBD’s influence on the brain’s serotonin receptors.

CBD and Chronic Pain

CBD may also help relieve chronic pain related to a variety of conditions. This possibility is likely because of CBD’s impact on endocannabinoid receptors, which are described below in further detail. A number of recent studies have pointed to CBD effectiveness in treating pain related to arthritis and multiple sclerosis. One particular study involved 47 individuals suffering from multiple sclerosis. Like the previously mentioned study, the individuals in this group showed significant signs of improvement compared to the placebo group.

CBD and the Endocannabinoid System

The endocannabinoid system was discovered by researchers exploring the effects of cannabis on the human body. Named after cannabis, this system is responsible for regulating the body’s internal balance (homeostasis). It is comprised of endocannabinoids and corresponding receptors, which are found throughout the body, including in the brain and vital organs. They are primarily responsible for the euphoria that accompanies working out and other physical activity.

CBD and Cancer

CBD could potentially prove beneficial in treating cancer-related side effects like nausea, pain, and even vomiting. It could also assist with individuals undergoing chemotherapy, where it is thought to aid in the prevention of nausea and vomiting. One study involved over 150 cancer patients who were not finding relief with their prescribed pain medication. One group was treated with a combination of CBD and THC while another was treated solely with THC. Those in the former group allegedly showed significant signs of pain reduction compared to those in the latter group.

CBD and Drug-Resistant Bacteria

CBD may help destroy drug-resistant bacteria. If this is indeed the case, it could prove to be a valuable tool in the battle against superbugs, which are becoming increasingly problematic as time goes on. However, more research is required to determine whether or not this is actually the case.

CBD and Neurological Disorders

Some researchers theorize that CBD’s impact on the endocannabinoid system means it can adequately benefit those with neurological disorders such as multiple sclerosis and epilepsy. Additionally, one specific study concluded that CBD may significantly reduce seizures experienced by children suffering from Dravet syndrome, which is similar to epilepsy. Further studies indicate that CBD could even help individuals with Parkinson’s disease, Alzheimer’s disease, and general cognitive degradation, though research is still ongoing.

CBD and the Human Heart

CBD is thought to benefit the heart and circulatory system as well. Here, one of its most profound potentials is that it may be effective in reducing high blood pressure, a condition that can spur a number of serious health conditions, including heart attacks and strokes. Some researchers postulate that CBD’s anti-anxiety properties are directly correlated with its effect on blood pressure.

CBD and Weight

One of the many potential benefits of cannabidiol is the ability to affect the genes and proteins responsible for breaking down fat and promoting healthy blood sugar levels. It may also promote the growth of the mitochondria responsible for burning calories.

Another potential weight-related benefit of CBD is that it may be able to convert white fat into brown fat. White fat is what we normally think of in regards to body fat, while brown fat can potentially improve health by regulating blood sugar and burning white fat.

Other Potential Benefits

In addition to everything summarized above, CBD has also been noted for its potential to treat several other health issues, including schizophrenia and related disorders, drug addiction and substance abuse disorders, diabetes, and various forms of cancer in animals.

The Potential Side Effects of CBD

While most people consider CBD to be safe, there have been a few reported side effects that people should be aware of, as they may result in adverse reactions. These include changes in appetite, diarrhea, depression, and general fatigue. It can also have an adverse reaction when combined with certain medications, so be sure to consult a doctor if you are currently taking prescribed medication.

CBD Bioavailability and You

These days CBD is available in a variety of forms, including capsules, oils, liquids, tinctures, lotions, and much more. Each form is ingested in a slightly different manner, while each product features a different concentration of CBD. The sheer number of options can be quite overwhelming, especially to those just starting out.

Before trying CBD, most people figure out what method is best for them and research the proper dosage. This is precisely where CBD bioavailability comes in.

Bioavailability pertains to how quickly a substance is absorbed into the bloodstream. In other words, it is the determining factor between dosage and effect. Bioavailability is automatically calculated into the standard dosage of all prescription medication. With this in mind, it is important to know that CBD bioavailability fluctuates in accordance with two factors: the overall concentration and the method of consumption. The next step, then, is determining which ingestion method is right for you.

Getting the Most Bioavailability from Your CBD

As with most substances, the quickest means of ingestion is a direct injection into the bloodstream. Obviously this would be administered intravenously via syringe and would deliver the full effect of CBD. However, you would also be sticking yourself with a needle, which isn’t all that appealing—so let’s move on to more palatable methods.

Oral Consumption and CBD Bioavailability

Oral consumption, as most of us know, is when a substance is ingested through the mouth. As far as CBD is concerned, methods of oral consumption include edibles, beverages, and capsules. Edibles can include chocolate, ice cream, gummy candies, and more.

Oral consumption can certainly be a healthier route than smoking—however, ingesting orally means the substance is metabolized and digested, which ultimately reduces CBD bioavailability. Several recent studies aimed at testing the bioavailability of CBD found rates between 4% and 20%, which is ultimately pretty low. To put it in perspective, a 20% CBD bioavailability rate means that, once ingested, a mere 20mg reaches the bloodstream. This means that 75% of the CBD in your edible is lost to your digestive system. This is no reason to fear, however, because there are a few other methods of ingestion that should increase your CBD bioavailability rate to more optimal levels.

Under the Tongue: The Potential Benefits of Sublingual Consumption

Administering CBD to one’s sublingual gland, which is located underneath the tongue, allows it to be absorbed directly into the bloodstream. Traditional sublingual administration methods include CBD lozenges, CBD sprays, and even CBD tinctures. Which one you select depends on your personal preference. Be sure to check the overall dosage amount and ask a professional if you have questions.

Users should consider approaching sublingual consumption with caution. In terms of CBD bioavailability, sublingual consumption usually impacts the user more directly. Beyond that, it also achieves a much higher availability since its effects are only minimized by enzymes in the user’s saliva.

The primary factors that affect CBD bioavailability within the context of sublingual administration primarily revolve around the quality of the CBD, with reported rates fluctuating between 12% and 35%. When compared to oral consumption, the amount of bioavailable CBD is much higher.

Vaporizing CBD

Another method of consuming CBD involves inhaling it straight into the lungs, where it passes through alveoli, which sounds like a type of pasta but in reality are actually small air sacks. Alveoli transfer the carbon dioxide and oxygen between the lungs and bloodstream, providing an optimal avenue for CBD to travel through. This allows CBD to avoid first-pass metabolism, which could result in a much higher bioavailability rate than oral consumption.

The instrument used is typically a vaporizer or “vape pen”. After passing through the lungs, CBD enters the bloodstream, resulting in much higher bioavailability rates. Just how much are we talking about here? Several recent studies yielded bioavailability rates between 34 percent all the way up to 56 percent, making vaporizing one of the most effective means of ingesting CBD, even when compared to sublingual consumption. However, this is not to suggest that there are not any drawbacks. For example, bioavailability fluctuates in accordance with the various dynamics inherent in smoking, which include how long a hit is held, intervals between puffs, and the volume of material inhaled.
Understanding CBD bioavailability could result in a more fruitful and safer experience, as you might be able to ascertain the perfect dosage for your condition. Additionally, it helps your wallet by keeping you from spending too much on inferior products.

What Are Factors Affecting Bioavailability?

You may be asking yourself, what are the factors affecting bioavailability? Well, bioavailable CBD does not naturally dissolve in water; rather, when it diffuses from the bloodstream it subsequently finds its way into the user’s fatty tissue. This trajectory drastically reduces the overall amount of CBD available within the user’s system, resulting in lower bioavailability rates. Again, this can usually be modified by factors like dosage and potency.

Front Range Organics provides premium CBD oil for wellness. Founded in 2019 in Fort Collins, CO, the company has used CBD for an array of issues and wholeheartedly believes in its therapeutic benefits. They produce a range of CBD oils and softgels that are naturally grown on various farms throughout Colorado. Their closely monitored process ensures that their extraction methods remain pure and safe.

In addition to offering the best CBD products available online, Front Range Organics provides the best customer service in the business. One order is all it takes to see the level of dedication they infuse into their craft. Their products are actively curated in order to ensure the best quality, accuracy, and availability. So before you scour the market for your CBD related needs, visit their website, because odds are they have exactly what you’re looking for and more.

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